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NEUROLOGY 2005;65:1198-1202
© 2005 American Academy of Neurology

Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

J. Roquer, MD, PhD, A. Rodríguez Campello, MD, M. Gomis, MD, A. Ois, MD, E. Munteis, MD and P. Böhm, MSc

From the Stroke Unit, Department of Neurology of Hospital del Mar, Barcelona, Spain (Drs. Roquer, Rodríguez Campello, Gomis, Ois, and Munteis); and i3 Research (Mr. Böhm).

Address correspondence and reprint requests to Dr. Jaume Roquer, Servei de Neurologia, Hospital del Mar, Passeig Maritim 25-29, 08003 Barcelona, Spain; e-mail: 35826{at}imas.imim.es

Objective: To test the hypothesis that low serum cholesterol and low serum triglyceride levels at admission are related to an increase of in-hospital mortality in patients with first-ever supratentorial spontaneous intracerebral hemorrhage (ICH).

Methods: The authors obtained the serum cholesterol and triglyceride levels during the first 48 hours after first-ever ICH in 184 patients. They analyzed the impact of serum cholesterol and triglyceride concentrations on the in-hospital mortality after adjustment for possible confounding variables according to the results of the univariate analysis (age, hemorrhage volume, intraventricular extension, glycemia, serum albumin, and Glasgow Coma Scale score at admission) using the Cox proportional hazards model. They also analyzed the survival curves according to the cholesterol and triglyceride quartiles.

Results: Low serum cholesterol (p = 0.002; hazard ratio [HR] 0.988 [95% CI 0.979 to 0.997] mg/dL) and low serum triglyceride (p = 0.011; HR 0.986 [95% CI 0.976 to 0.997] mg/dL) concentrations were independently associated with increased in-hospital mortality after ICH. Analyzed by quartiles, the HR of in-hospital mortality was 3.136 (95% CI 0.833 to 11.087) for patients in the lowest cholesterol quartile (<166 mg/dL) and 3.484 (95% CI 1.088 to 11.155) for patients in the lowest triglyceride quartile (<74 mg/dL).

Conclusions: Low serum cholesterol and triglyceride levels obtained during the first hours after intracerebral hemorrhage (ICH) are strong independent predictors of in-hospital mortality in patients with spontaneous supratentorial ICH.

Disclosure: The authors report no conflicts of interest.

Received March 1, 2005. Accepted in final form July 8, 2005.






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