| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Diagnostic Radiology and MR Research Laboratory (Drs. Jack and Gunter, Ms. Shiung), Neurology (Drs. Knopman, Boeve, and Petersen), Health Sciences Research (Dr. O’Brien, Mr. Weigand), Psychiatry and Psychology (Drs. Smith and Ivnik), and Internal Medicine (Dr. Tangalos), Mayo Clinic and Foundation, Rochester, MN.
Address correspondence and reprint requests to Dr. Clifford R. Jack, Jr., Mayo Clinic, Department of Radiology, 200 First Street SW, Rochester, MN 55905; e-mail: jack.clifford{at}mayo.edu
Objective: To test the hypothesis that the atrophy rate measured from serial MRI studies is associated with time to subsequent clinical conversion to a more impaired state in both cognitively healthy elderly subjects and in subjects with amnestic mild cognitive impairment (MCI).
Methods: Ninety-one healthy elderly patients and 72 patients with amnestic MCI who met inclusion criteria were identified from the Mayo Alzheimer’s Disease Research Center and Alzheimer’s Disease Patient Registry. Atrophy rates of four different brain structures—hippocampus, entorhinal cortex, whole brain, and ventricle—were measured from a pair of MRI studies separated by 1 to 2 years. The time of the second scan marked the beginning of the clinical observation period.
Results: During follow-up, 13 healthy patients converted to MCI or Alzheimer disease (AD), whereas 39 MCI subjects converted to AD. Among those healthy at baseline, only larger ventricular annual percent volume change (APC) was associated with a higher risk of conversion (hazard ratio for a 1-SD increase 1.9, p = 0.03). Among MCI subjects, both greater ventricular volume APC (hazard ratio for a 1-SD increase 1.7, p < 0.001) and greater whole brain APC (hazard ratio for a 1-SD increase 1.4, p = 0.007) increased the risk of conversion to AD. Both ventricular APC (hazard ratio for a 1-SD increase 1.59, p = 0.001) and whole brain APC (hazard ratio for a 1-SD increase 1.32, p = 0.009) provided additional predictive information to covariate-adjusted cross-sectional hippocampal volume at baseline about the risk of converting from MCI to AD.
Discussion: Higher whole brain and ventricle atrophy rates 1 to 2 years before baseline are associated with an increased hazard of conversion to a more impaired state. Combining a measure of hippocampal volume at baseline with a measure of either whole brain or ventricle atrophy rates from serial MRI scans provides complimentary predictive information about the hazard of subsequent conversion from mild cognitive impairment to Alzheimer disease. However, overlap among those who did vs those who did not convert indicate that these measures are unlikely to provide absolute prognostic information for individual patients.
Supported by the National Institute on Aging (AG16574, AG06786, and AG11378), and The Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program.
Disclosure: The authors report no conflicts of interest.
Received November 3, 2004. Accepted in final form July 8, 2005.
This article has been cited by other articles:
|
|
 |
|
  R. S. Desikan, B. Fischl, H. J. Cabral, T. L. Kemper, C.R.G. Guttmann, D. Blacker, B. T. Hyman, M. S. Albert, and R. J. Killiany MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD Neurology, September 9, 2008; 71(11): 819 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Nestor, R. Rupsingh, M. Borrie, M. Smith, V. Accomazzi, J. L. Wells, J. Fogarty, R. Bartha, and the Alzheimer's Disease Neuroimaging Initiative Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database Brain, September 1, 2008; 131(9): 2443 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Bruen, W. J. McGeown, M. F. Shanks, and A. Venneri Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease Brain, September 1, 2008; 131(9): 2455 - 2463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Sluimer, W. M. van der Flier, G. B. Karas, N. C. Fox, P. Scheltens, F. Barkhof, and H. Vrenken Whole-Brain Atrophy Rate and Cognitive Decline: Longitudinal MR Study of Memory Clinic Patients Radiology, August 1, 2008; 248(2): 590 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Colliot, G. Chetelat, M. Chupin, B. Desgranges, B. Magnin, H. Benali, B. Dubois, L. Garnero, F. Eustache, and S. Lehericy Discrimination between Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging by Using Automated Segmentation of the Hippocampus Radiology, July 1, 2008; 248(1): 194 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Mueller and B. C. Dickerson Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer disease Neurology, May 6, 2008; 70(19_Part_2): 1728 - 1729. [Full Text] [PDF]
|
|
|
|
|
|
C. R. Jack Jr, S. D. Weigand, M. M. Shiung, S. A. Przybelski, P. C. O'Brien, J. L. Gunter, D. S. Knopman, B. F. Boeve, G. E. Smith, and R. C. Petersen Atrophy rates accelerate in amnestic mild cognitive impairment Neurology, May 6, 2008; 70(19_Part_2): 1740 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Karas, J. Sluimer, R. Goekoop, W. van der Flier, S.A.R.B. Rombouts, H. Vrenken, P. Scheltens, N. Fox, and F. Barkhof Amnestic Mild Cognitive Impairment: Structural MR Imaging Findings Predictive of Conversion to Alzheimer Disease AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Carlson, M. M. Moore, A. Dame, D. Howieson, L. C. Silbert, J. F. Quinn, and J. A. Kaye Trajectories of brain loss in aging and the development of cognitive impairment Neurology, March 11, 2008; 70(11): 828 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Jack Jr, V. J. Lowe, M. L. Senjem, S. D. Weigand, B. J. Kemp, M. M. Shiung, D. S. Knopman, B. F. Boeve, W. E. Klunk, C. A. Mathis, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment Brain, March 1, 2008; 131(3): 665 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Whitwell, M. M. Shiung, S. A. Przybelski, S. D. Weigand, D. S. Knopman, B. F. Boeve, R. C. Petersen, and C. R. Jack Jr MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment Neurology, February 12, 2008; 70(7): 512 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Fleisher, S. Sun, C. Taylor, C. P. Ward, A. C. Gamst, R. C. Petersen, C. R. Jack Jr, P. S. Aisen, L. J. Thal, and For the Alzheimer's Disease Cooperative Study Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment Neurology, January 15, 2008; 70(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Smith, S. Egorova, D. Blacker, R. J. Killiany, A. Muzikansky, B. C. Dickerson, R. E. Tanzi, M. S. Albert, S. M. Greenberg, and C. R. G. Guttmann Magnetic Resonance Imaging White Matter Hyperintensities and Brain Volume in the Prediction of Mild Cognitive Impairment and Dementia Arch Neurol, January 1, 2008; 65(1): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R I SCAHILL and N C FOX Longitudinal imaging in dementia Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S92 - S98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E V SULLIVAN and A PFEFFERBAUM Neuroradiological characterization of normal adult ageing Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S99 - S108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. van de Pol, W. M. van der Flier, E.S.C. Korf, N. C. Fox, F. Barkhof, and P. Scheltens Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment Neurology, October 9, 2007; 69(15): 1491 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Whitwell, S. A. Przybelski, S. D. Weigand, D. S. Knopman, B. F. Boeve, R. C. Petersen, and C. R. Jack Jr 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease Brain, July 1, 2007; 130(7): 1777 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Kemppainen, S. Aalto, I. A. Wilson, K. Nagren, S. Helin, A. Bruck, V. Oikonen, M. Kailajarvi, M. Scheinin, M. Viitanen, et al. PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment Neurology, May 8, 2007; 68(19): 1603 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Smith, H. Chebrolu, D. R. Wekstein, F. A. Schmitt, G. A. Jicha, G. Cooper, and W. R. Markesbery Brain structural alterations before mild cognitive impairment Neurology, April 17, 2007; 68(16): 1268 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Jefferson, J. M. Massaro, P. A. Wolf, S. Seshadri, R. Au, R. S. Vasan, M. G. Larson, J. B. Meigs, J. F. Keaney Jr, I. Lipinska, et al. Inflammatory biomarkers are associated with total brain volume: The Framingham Heart Study Neurology, March 27, 2007; 68(13): 1032 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Devanand, G. Pradhaban, X. Liu, A. Khandji, S. De Santi, S. Segal, H. Rusinek, G. H. Pelton, L. S. Honig, R. Mayeux, et al. Hippocampal and entorhinal atrophy in mild cognitive impairment: Prediction of Alzheimer disease Neurology, March 13, 2007; 68(11): 828 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sunderland, H. Hampel, M. Takeda, K. T. Putnam, and R. M. Cohen Biomarkers in the Diagnosis of Alzheimer's Disease: Are We Ready? J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 172 - 179. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
