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Eye movement abnormalities in stiff person syndrome

From the Beckman Vision Center, University of California, San Francisco, CA.

Address correspondence and reprint requests to Dr. Jonathan C. Horton, Beckman Vision Center, University of California San Francisco, 10 Koret Way, San Francisco, CA, 94143-0730; e-mail: horton{at}itsa.ucsf.edu.

The authors describe a 38-year-old woman with stiff person syndrome (SPS) and gaze-holding nystagmus, limited abduction, vertical and horizontal ocular misalignment, deficient smooth pursuit, and impaired saccade initiation. There was no evidence of ocular myasthenia, indicating that abnormalities of ocular motor function can occur as a primary manifestation of SPS, perhaps from depletion of GABA.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 8 issue to find the title link for this article.

Supported by the National Eye Institute (EY015343, EY10217, and EY02162), the Larry L. Hillblom Foundation, and Research to Prevent Blindness.

Disclosure: The authors report no conflicts of interest.

Received April 1, 2005. Accepted in final form July 12, 2005.

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				P L Guardado Santervas, A Arjona Padillo, P Serrano Castro, J Olivares Romero, J Rubi Callejon, G Alonso Verdegay, and A Huete Hurtado Stiff person syndrome (SPS), a basal ganglia disease? Striatal MRI lesions in a patient with SPS J. Neurol. Neurosurg. Psychiatry, June 1, 2007; 78(6): 657 - 659. [Full Text] [PDF]

				C. R. Gordon, A. Z. Zivotofsky, T. Siman-Tov, N. Gadoth, and M. C. Dalakas Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies Neurology, April 3, 2007; 68(14): 1161 - 1161. [Full Text] [PDF]