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NEUROLOGY 2005;65:1474-1475
© 2005 American Academy of Neurology
Brief Communications

APOE {varepsilon}2/{varepsilon}4 polymorphism and cerebral microbleeds on gradient-echo MRI

M. Kim, MD, PhD, H. J. Bae, MD, PhD, J. Lee, PhD, L. Kang, MS, S. Lee, MD, S. Kim, MS, J. E. Lee, PhD, K. M. Lee, MD, PhD, B. W. Yoon, MD, PhD, O. Kwon, MD, J. S. Koo, MD and B. K. Kim, MD, PhD

From the Departments of Neurology (Drs. Bae, Kwon, Koo, and S. Kim), Eulji General Hospital, Eulji University School of Medicine, and Seoul National University Hospital (Drs. M. Kim, Kang, S. Lee, K.M. Lee, and Yoon), Department of Preventive Medicine (Dr. J. Lee), School of Medicine, Korea University, and DNA Link, Inc. (Drs. Kim and J.E. Lee), Seoul, Korea.

Address correspondence and reprint requests to Dr. H.-J. Bae, Department of Neurology, Eulji General Hospital, Eulji University School of Medicine, 280-1 Beonji, Hagye 1 Dong, Nowon Gu, Seoul 139-711, Republic of Korea; e-mail: bhj1405{at}eulji.or.kr.

The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the {varepsilon}2 or {varepsilon}4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.69 to 2.11) for nonlobar CMBs. This suggests that the pathogenesis of CMBs may differ depending on their location.

Supported by a grant from the Korea Health 21 R&D Project (Ministry of Health and Welfare, Republic of Korea [03-PJ10-PG13-GD01-0002]) and the 2002 Eulji Research Grant (Eulji University School of Medicine).

Disclosure: The authors report no conflicts of interest.

Received January 20, 2005. Accepted in final form July 19, 2005.




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