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NEUROLOGY 2005;65:1483-1486
© 2005 American Academy of Neurology
Brief Communications

Gray matter decrease in patients with chronic tension type headache

T. Schmidt-Wilcke, MD, E. Leinisch, MD, A. Straube, MD, PhD, N. Kämpfe, MD, B. Draganski, MD, H. C. Diener, MD, PhD, U. Bogdahn, MD, PhD and A. May, MD

From the Department of Neurology (Drs. Schmidt-Wilcke, Leinisch, Kämpfe, Draganski, Bogdahn, May), University of Regensburg, Regensburg, Germany; Department of Neurology (Dr. Straube), University of Munich, Munich, Germany; Department of Neurology (Dr. Diener), University of Essen, Essen, Germany; and Department of Systems Neuroscience (Dr. May), University of Hamburg, Hamburg, Germany.

Address correspondence and reprint requests to Dr. Arne May, Department of Systems Neuroscience, Universitäts-Krankenhaus Eppendorf (UKE), Martinistr. 52, D-20246 Hamburg, Germany; e-mail: a.may{at}uke.uni-hamburg.de

Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.com and scroll down the Table of Contents for the November 8 issue to find the title link for this article.

Supported by a grant of the BMBF (project no. 371 57 01). A.M. is supported by a grant from the Deutsche Forschungsgemeinschaft (MA 1862/2).

Disclosure: The authors report no conflicts of interest.

Received May 3, 2005. Accepted in final form July 19, 2005.




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