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NEUROLOGY 2005;65:1487-1489
© 2005 American Academy of Neurology
Brief Communications

Serum anticholinergic activity, white matter hyperintensities, and cognitive performance

R. D. Nebes, PhD, B. G. Pollock, MD, PhD, C. C. Meltzer, MD, J. A. Saxton, PhD, P. R. Houck, MS, E. M. Halligan, MA and S. T. DeKosky, MD

From the Departments of Psychiatry (Drs. Nebes, Pollock, Meltzer, Saxton, Houck, Halligan, and DeKosky), Department of Radiology (Drs. Meltzer), and Department of Neurology (Drs. Saxton and DeKosky), University of Pittsburgh Medical Center, Pittsburgh, PA.

Address correspondence and reprint requests to Dr. Robert D. Nebes, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213; e-mail: nebesrd{at}upmc.edu

The authors investigated whether the cognitive impairments associated with white matter hyperintensities (WMH) in normal elderly subjects are exacerbated by any anticholinergic medications being taken by the subjects. Results showed serum anticholinergic activity (SAA) and WMH volume to have a synergistic interaction such that the cognitive decrements associated with increasing WMH volume were greatest in those older individuals in the highest quartile of the SAA distribution.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 8 issue to find the link for this article.

Supported by grants from the National Institute on Aging (AG019151, AG14051, AG05133) and the National Institute of Mental Health (MH59945, MH59666, MH65416, MH52247, MH645625).

Disclosure: The authors report no conflicts of interest.

Received February 2, 2005. Accepted in final form July 19, 2005.




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