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NEUROLOGY 2005;65:1490-1492
© 2005 American Academy of Neurology
Brief Communications

CSF amyloid ß42 and tau levels correlate with AIDS dementia complex

B. J. Brew, MBBS, MD, FRACP, L. Pemberton, BSc, K. Blennow, MD, PhD, A. Wallin, MD, PhD and L. Hagberg, MD

From the Departments of Neurology (Dr. Brew) and HIV Medicine (Dr. Brew) and Centre for Immunology (Ms. Pemberton), St. Vincent's Hospital, University of New South Wales, Sydney, Australia; Department of Clinical Neuroscience, University of Göteborg, Sahlgren's University Hospital, Mölndal, Sweden (Drs. Blennow and Wallin); and Department of Infectious Diseases, University of Goteborg, Sahlgrenska University Hospital, Goteborg, Sweden (Dr. Hagberg).

Address correspondence and reprint requests to Dr. Bruce J. Brew, Department of Neurology, Level 4 Xavier Building, Victoria St. Darlinghurst, Sydney, Australia 2010; e-mail: b.brew{at}unsw.edu.au

There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF ß-amyloid(1-42) (Aß42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF Aß42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.

Supported in part by National Institutes of Health grant NS43103.

Disclosure: The authors report no conflicts of interest.

Received January 21, 2005. Accepted in final form July 20, 2005.




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