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NEUROLOGY 2005;65:1499-1501
© 2005 American Academy of Neurology
Brief Communications

Bilateral isolated phrenic neuropathy causing painless bilateral diaphragmatic paralysis

P. T. Lin, MD, P. -B. Andersson, MBChB, DPhil, B. J. Distad, MD, R. J. Barohn, MD, S. C. Cho, MD, Y. T. So, MD, PhD and J. S. Katz, MD

From the Department of Neurology (Drs. Lin, Andersson, Cho, So, and Katz), Stanford University, Stanford, CA; the Department of Neurology (Dr. Katz), California Pacific Medical Center, San Francisco, CA; the Department of Neurology (Dr. Distad), University of Washington, Seattle, WA; and the Department of Neurology (Dr. Barohn), University of Kansas Medical Center, Kansas City, KS.

Address correspondence and reprint requests to Dr Lin, Department of Neurology, Stanford University, 300 Pasteur Dr., Room A343, Stanford, CA 94305; e-mail: perlin{at}leland.stanford.edu

The authors report four patients with a syndrome of painless bilateral isolated phrenic neuropathy. Electrophysiologic testing demonstrated active denervation restricted to the diaphragm. Long-term recovery was poor. The authors conclude that bilateral isolated phrenic neuropathy is a cause of painless diaphragmatic paralysis distinguishable from immune brachial plexus neuropathy and other neuromuscular disorders with similar clinical presentation.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 8 issue to find the link for this article.

Disclosure: The authors report no conflicts of interest.

Received March 28, 2005. Accepted in final form July 19, 2005.




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B. E. Tsao, D. A. Ostrovskiy, A. J. Wilbourn, and R. W. Shields Jr
Phrenic neuropathy due to neuralgic amyotrophy
Neurology, May 23, 2006; 66(10): 1582 - 1584.
[Abstract] [Full Text] [PDF]


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