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Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration

From the Departments of Radiology (J.L.W., C.R.J., M.L.S.) and Neurology (K.A.J.), Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. Keith A Josephs, Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905; e-mail: josephs.keith{at}mayo.edu

The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.

Editorial, see page 8

See also page 41

Supported by grants P50 AG16574, A611378, and U01 AG06786 from the National Institute on Aging, Bethesda, MD, and by the Robert H. and Clarice Smith and Abigail Van Buren AD Research Programs of the Mayo Foundation.

Disclosure: The authors report no conflicts of interest.

Received June 16, 2005. Accepted in final form September 21, 2005.

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