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Published online before print November 16, 2005, doi:10.1212/01.wnl.0000188757.38495.23)
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NEUROLOGY 2006;66:105-107
© 2006 American Academy of Neurology
Brief Communications

Autologous peripheral blood stem cell transplantation for POEMS syndrome

S. Kuwabara, MD, S. Misawa, MD, K. Kanai, MD, Y. Kikkawa, MD, M. Nishimura, MD, C. Nakaseko, MD, R. K. Cho, MD and T. Hattori, MD

From the Departments of Neurology (Drs. Kuwabara, Misawa, Kanai, Kikkawa, and Hattori) and Hematology (Drs. Nishimura Nakaseko, and Cho), Chiba University School of Medicine, Japan.

Address correspondence and reprint requests to Dr. S. Kuwabara, Department of Neurology, Graduate School of Medicine, Chiba University 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670 Japan; e-mail: kuwabara-s{at}faculty.chiba-u.jp

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.

Editorial, see page 10

This article was previously published in electronic format on November 16, 2005, as an Expedited E-Pub at www.neurology.org.

Supported in part by a research grant for Neuroimmunological Disease (S.K.) from the Ministry of Health, Labor, and Welfare of Japan.

Disclosure: The authors report no conflicts of interest.

Received June 20, 2005. Accepted in final form August 15, 2005.




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