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NEUROLOGY 2006;66:118-120
© 2006 American Academy of Neurology


Brief Communications

Plaque density on CT, a potential marker of ischemic stroke

J. M. Serfaty, MD, PhD, M. Nonent, MD, N. Nighoghossian, MD, PHD, F. Rouhart, MD, L. Derex, MD, PHD, C. Rotaru, MD, P. Chirossel, MD, G. Thabut, MD, B. Guias, MD, J-F Heautot, MD, P. Gouny, MD, A. de la Vega, MD, C. Pachai, PhD, R. Ecochard, MD, J. Villard, MD, P. C. Douek, MD, PhD for the CARMEDAS Study Group*

From the Departments of Radiology (J.-M.S., C.R., P.C., A.D.L.V., P.C.D.), Neurology (L.D., N.N.), and Biostatistics (R.E.), University Hospital Center, Lyon; Department of Radiology (J.M.S.) and Biostatistics (G.T.), Hôpital Xavier Bichat, Paris; Departments of Radiology (M.N.), Vascular Medicine (B.G.), Neurology (F.R.), and Vascular Surgery (P.G.), University Hospital Center Brest; Department of Radiology, University Hospital Center, Rennes (J.F.-H.); TheralysR (C.P.), Lyon, France.

Address correspondence and reprints requests to Dr. Jean-Michel Serfaty, Department of Radiology and CREATIS, Hôpital Cardiovasculaire et Pneumologique L. Pradel, 28 rue du Doyen Lepine, 69500 Bron, France; e-mail: jean-michel.serfaty{at}bch.aphp.fr

The authors sought to determine in a retrospective analysis whether carotid plaque soft TD on CT is associated with recent ischemic neurologic events. Among 141 patients (99 asymptomatic), 106 plaques with more than 50% stenosis were selected for density measurements. They found an odds ratio for neurologic events associated with a 10-point decrease in density of 1.54 (p = 0.002), showing an association between plaque density and neurologic events.


* See the Appendix for a list of Group members.

Funded by a grant (PHRC 98) from the French Ministry of Health.

Disclosure: The authors report no conflicts of interest

Received June 20, 2005. Accepted in final form September 28, 2005.







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