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Published online before print November 9, 2005, doi:10.1212/01.wnl.0000188667.66646.1c)
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NEUROLOGY 2006;66:127-130
© 2006 American Academy of Neurology
Brief Communications

Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma

M. K. Sharma, PhD, M. A. Watson, MD, PhD, M. Lyman, BS, A. Perry, MD, K. D. Aldape, MD, F. Deák, PhD and D. H. Gutmann, MD, PhD

From the Departments of Neurology (Drs. Sharma and Gutmann, M. Lyman) and Pathology and Immunology (Drs. Watson and Perry), Washington University School of Medicine, St. Louis, MO, Department of Pathology (Dr. Aldape), University of Texas M.D. Anderson Cancer Center, Houston, and Institute of Biochemistry (Dr. Deák), Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary.

Address correspondence and reprint requests to Dr Gutmann, Department of Neurology, Washington University School of Medicine, Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110; e-mail: gutmannd{at}neuro.wustl.edu

Using whole genome expression microarray technology to discover clinically relevant biomarkers for pilocytic astrocytoma (PA), the authors identified matrilin-2 as a unique mRNA overexpressed in PA. Matrilin-2 protein expression was similarly elevated in the majority of sporadic PA, but in only one neurofibromatosis 1-associated PA with an unusually aggressive clinical phenotype. These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive PA.

This article was previously published in electronic format on November 9, 2005, as an Expedited E-Pub at www.neurology.org.

Supported by Schnuck Markets, Inc. (D.H.G.), and OM-255/02 (F.D.).

Disclosure: The authors report no conflicts of interest.

Received July 14, 2005. Accepted in final form September 23, 2005.




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