HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Data Supplement Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zahuranec, D. B. Articles by Morgenstern, L. B. Search for Related Content PubMed PubMed Citation Articles by Zahuranec, D. B. Articles by Morgenstern, L. B.

Differences in intracerebral hemorrhage between Mexican Americans and non-Hispanic whites

From the Stroke Program (D.B.Z., D.L.B., L.D.L., M.A.S., N.M.G., L.B.M.) and Department of Neurosurgery (S.V.E.), University of Michigan Medical School, Ann Arbor; Stroke Program (N.R.G.), University of Texas Medical School at Houston; Practicing Neurologist (P.J.L.), Corpus Christi, TX; and Department of Epidemiology (L.B.M.), University of Michigan School of Public Health, Ann Arbor.

Address correspondence and reprint requests to Dr. Lewis B. Morgenstern, University of Michigan Medical School, 1500 East Medical Center Drive, TC 1920/0316, Ann Arbor, MI 48109-0316; e-mail: LMorgens{at}umich.edu

Background: Mexican Americans (MAs) have higher incidence rates of intracerebral hemorrhage (ICH) than non-Hispanic whites (NHWs). The authors present clinical and imaging characteristics of ICH in MAs and NHWs in a population-based study.

Methods: This work is part of the Brain Attack Surveillance in Corpus Christi (BASIC) project. Cases of nontraumatic ICH were identified from 2000 to 2003. Multivariable logistic regression was used to assess the independent associations between ethnicity and ICH location (lobar vs nonlobar) and volume (30 vs <30 mL), adjusting for demographics and baseline clinical characteristics. Logistic regression was also used to determine the association between ethnicity and in-hospital mortality, adjusting for confounders.

Results: A total of 149 MAs and 111 NHWs with ICH were identified. MAs were younger (70 vs 77, p < 0.001), more often male (55% vs 42%, p = 0.04), had a lower prevalence of atrial fibrillation (2.0% vs 13%, p < 0.001), and a higher prevalence of diabetes (39% vs 19%, p < 0.001). MA ethnicity was independently associated with nonlobar hemorrhage (OR 2.08, 95% CI: 1.15, 3.70). MAs had over two times the odds of having small (<30 mL) hemorrhages compared with NHWs (OR = 2.41, 95% CI: 1.31, 4.46). NHWs had higher in-hospital mortality, though this association was no longer significant after adjustment for ICH volume, location, age, and sex.

Conclusions: There are significant differences in the characteristics of ICH in MAs and NHWs, with MA patients more likely to have smaller, nonlobar hemorrhages. These differences may be used to examine the underlying pathophysiology of ICH.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 10 issue to find the title link for this article.

Funded by NIH RO1 NS38916.

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form October 4, 2005.

This article has been cited by other articles:

				H. Kim, S. Sidney, C. E. McCulloch, K. Y. T. Poon, V. Singh, S. C. Johnston, N. U. Ko, A. S. Achrol, M. T. Lawton, R. T. Higashida, et al. Racial/Ethnic Differences in Longitudinal Risk of Intracranial Hemorrhage in Brain Arteriovenous Malformation Patients Stroke, September 1, 2007; 38(9): 2430 - 2437. [Abstract] [Full Text] [PDF]

				D. B. Zahuranec, D. L. Brown, L. D. Lisabeth, N. R. Gonzales, P. J. Longwell, M. A. Smith, N. M. Garcia, and L. B. Morgenstern Early care limitations independently predict mortality after intracerebral hemorrhage Neurology, May 15, 2007; 68(20): 1651 - 1657. [Abstract] [Full Text] [PDF]