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Published online before print March 15, 2006, doi:10.1212/01.wnl.0000206364.19772.39)
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 Volume 66, Number 10, May 23, 2006
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NEUROLOGY 2006;66:1571-1573
© 2006 American Academy of Neurology
Brief Communications

Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy

D. M. Andrade, MD, MSc, D. Zumsteg, MD, C. Hamani, MD, M. Hodaie, MD, MSc, FRCSC, S. Sarkissian, PhD, A. M. Lozano, MD, PhD, FRCSC and R. A. Wennberg, MD, MSc, FRCPC

From Divisions of Neurology (D.M.A., D.Z., S.S., R.A.W.) and Neurosurgery (C.H., M.H., A.M.L.), Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. Richard A. Wennberg, Toronto Western Hospital, 399 Bathurst Street, 5W444, Toronto, ON, Canada M5T 2S8; e-mail: r.wennberg{at}utoronto.ca

The authors describe long-term follow-up (mean, 5 years) in patients with anterior (AN) (n = 6) or centromedian (n = 2) thalamic deep brain stimulation (DBS) for epilepsy. Five patients (all AN) had ≥50% seizure reduction, although benefit was delayed in two until years 5 to 6, after changes in antiepileptic drugs. DBS electrode implantation in AN patients was followed by seizure reduction 1 to 3 months before active stimulation, raising the possibility of a beneficial microthalamotomy effect.

Editorial, see page 1468

See also page 1490

This article was previously published in electronic format as an Expedited E-Pub on March 15, 2006, at www.neurology.org.

Disclosure: Dr. Lozano and Dr. Wennberg are consultants for Medtronic, Inc.

Received September 1, 2005. Accepted in final form January 3, 2006.


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