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NEUROLOGY 2006;66:1577-1579
© 2006 American Academy of Neurology
Brief Communications

Narcolepsy–cataplexy associated with precocious puberty

G. Plazzi, MD, A. Parmeggiani, MD, E. Mignot, MD, L. Lin, MD, M. C. Scano, MD, A. Posar, MD, F. Bernardi, MD, R. Lodi, MD, C. Tonon, MD, B. Barbiroli, MD, P. Montagna, MD and A. Cicognani, MD

From the Department of Neurological Sciences, (G.P., A.P., M.C.S., A.P., P.M.), Department of Pediatrics (F.B., A.C.), and Department of Clinical Medicine and Applied Biotechnology "D. Campanacci" (R.L., C.T., B.B.), University of Bologna, Italy; and Howard Hughes Medical Institute (E.M., L.L.), Stanford University, CA.

Address correspondence and reprint requests to Dr. Giuseppe Plazzi, Dipartimento di Scienze Neurologiche dell’Università di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy; e-mail: giuseppe.plazzi{at}unibo.it

In children, narcolepsy may be the symptom of a brain lesion or genetic disease. The authors report two cases with severe narcolepsy–cataplexy emerging in childhood in close temporal association with obesity and precocious puberty.

The study was partially supported by NIH grant NS232724 to E. Mignot.

Disclosure: The authors report no conflicts of interest.

Received October 3, 2005. Accepted in final form February 7, 2006.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the May 23 issue to find the title link for this article.






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