Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
 Volume 66, Number 10, May 23, 2006
Right arrow Correspondence:
Submit a response
Right arrow Correspondence:
View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fernandez, C.
Right arrow Articles by Pellissier, J. -F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernandez, C.
Right arrow Articles by Pellissier, J. -F.
Related Collections
Right arrow Diagnostic test assessment
Right arrow Muscle disease
Right arrowRelated Article
NEUROLOGY 2006;66:1585-1587
© 2006 American Academy of Neurology
Brief Communications

Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia

C. Fernandez, MD, A. Maues de Paula, MD, D. Figarella-Branger, MD, PhD, M. Krahn, MD, R. Giorgi, MD, PhD, B. Chabrol, MD, M. -F. Monfort, MD, J. Pouget, MD and J. -F. Pellissier, MD

From the Laboratoire d'Anatomie Pathologique et Neuropathologie (C.F., A.M., D.F.-B., J.-F.P.), Laboratoire de Génétique (M.K.), Laboratoire de Biochimie (M.-F.M.), Service de Neurologie et Maladies Neuromusculaires (J.P.), Hôpital de la Timone Adultes, Marseille; LERTIM (R.G.), Faculté de Médecine, Marseille; and Service de Neuropédiatrie (B.C.), Hôpital de la Timone Enfants, Marseille, France.

Address correspondence and reprint requests to Dr. Jean-François Pellissier, Laboratoire d'Anatomie Pathologique et Neuropathologie, Hôpital de la Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; e-mail: Jean-Francois.Pellissier{at}medecine.univ-mrs.fr

The authors analyzed muscle biopsy specimens of 104 patients with creatine kinase activity greater than 500 UI/L (normal 10 to 170 UI/L) without signs of muscle weakness. They achieved a definite or probable diagnosis in 55% of cases. The most frequently identified diseases were glycogen storage diseases, muscular dystrophies, and inflammatory myopathies. The probability of making a diagnosis was higher in children and when creatine kinase level was greater than 2,000 UI/L.

Disclosure: The authors report no conflicts of interest.

Received September 22, 2005. Accepted in final form February 8, 2006.


Related Article

May 23 Highlights
Neurology 2006 66: 1462-1463. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G Gutierrez-Gutierrez, M Steiner, and O M M. S. Andres
Obstructive sleep apnoea syndrome: a possible cause of symptomatic hyperckaemia
J. Neurol. Neurosurg. Psychiatry, January 1, 2010; 81(1): 123 - 124.
[Full Text] [PDF]

Home page
 NeurologyHome page
R. H. Walker, J. J. Peters, H. H. Jung, A. Danek, C. Fernandez, D. Figarella-Branger, A. Maues De Paula, and J.-F. Pellissier
Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia
Neurology, February 13, 2007; 68(7): 535 - 536.
[Full Text] [PDF]

Correspondence:

Read all Correspondence

Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia
Ruth H. Walker, MB, ChB, PhD, et al.
Neurology Online, 12 Sep 2006 [Full text]
Reply from the Authors
Carla Fernandez, et al.
Neurology Online, 12 Sep 2006 [Full text]