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 Volume 66, Number 10, May 23, 2006
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NEUROLOGY 2006;66:1585-1587
© 2006 American Academy of Neurology
Brief Communications

Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia

C. Fernandez, MD, A. Maues de Paula, MD, D. Figarella-Branger, MD, PhD, M. Krahn, MD, R. Giorgi, MD, PhD, B. Chabrol, MD, M. -F. Monfort, MD, J. Pouget, MD and J. -F. Pellissier, MD

From the Laboratoire d'Anatomie Pathologique et Neuropathologie (C.F., A.M., D.F.-B., J.-F.P.), Laboratoire de Génétique (M.K.), Laboratoire de Biochimie (M.-F.M.), Service de Neurologie et Maladies Neuromusculaires (J.P.), Hôpital de la Timone Adultes, Marseille; LERTIM (R.G.), Faculté de Médecine, Marseille; and Service de Neuropédiatrie (B.C.), Hôpital de la Timone Enfants, Marseille, France.

Address correspondence and reprint requests to Dr. Jean-François Pellissier, Laboratoire d'Anatomie Pathologique et Neuropathologie, Hôpital de la Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France; e-mail: Jean-Francois.Pellissier{at}medecine.univ-mrs.fr

The authors analyzed muscle biopsy specimens of 104 patients with creatine kinase activity greater than 500 UI/L (normal 10 to 170 UI/L) without signs of muscle weakness. They achieved a definite or probable diagnosis in 55% of cases. The most frequently identified diseases were glycogen storage diseases, muscular dystrophies, and inflammatory myopathies. The probability of making a diagnosis was higher in children and when creatine kinase level was greater than 2,000 UI/L.

Disclosure: The authors report no conflicts of interest.

Received September 22, 2005. Accepted in final form February 8, 2006.


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R. H. Walker, J. J. Peters, H. H. Jung, A. Danek, C. Fernandez, D. Figarella-Branger, A. Maues De Paula, and J.-F. Pellissier
Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia
Neurology, February 13, 2007; 68(7): 535 - 536.
[Full Text] [PDF]

Correspondence:

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Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia
Ruth H. Walker, MB, ChB, PhD, et al.
Neurology Online, 12 Sep 2006 [Full text]
Reply from the Authors
Carla Fernandez, et al.
Neurology Online, 12 Sep 2006 [Full text]

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