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NEUROLOGY 2006;66:1591-1593
© 2006 American Academy of Neurology
Brief Communications

Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies

S. Zaja-Milatovic, MS, C. D. Keene, MD, PhD, K. S. Montine, PhD, J. B. Leverenz, MD, D. Tsuang, MD and T. J. Montine, MD, PhD

From the University of Washington, Seattle.

Address correspondence and reprint requests to Dr. Thomas J. Montine, Department of Pathology, University of Washington, Box 359791, Seattle, WA 98104; e-mail: tmontine{at}u.washington.edu

Dementia with Lewy bodies (DLB) is the second most common form of dementia and shows more severely impaired performance on tests of executive functions compared to Alzheimer disease. Here the authors demonstrate selective spinodendritic degeneration of medium spiny neurons in regions of the caudate nucleus that subserve executive functions and propose that this may underlie, at least in part, the heightened executive dysfunction observed in patients with DLB.

Supported by the Nancy and Buster Alvord Endowment and grants from the NIH (NS44282 and NS48595).

Disclosure: The authors report no conflicts of interest.

Received August 17, 2005. Accepted in final form February 16, 2006.




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M. L. Kramer and W. J. Schulz-Schaeffer
Presynaptic {alpha}-Synuclein Aggregates, Not Lewy Bodies, Cause Neurodegeneration in Dementia with Lewy Bodies
J. Neurosci., February 7, 2007; 27(6): 1405 - 1410.
[Abstract] [Full Text] [PDF]


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