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Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

Proteasomal dysfunction in sporadic Parkinson's disease

From the Department of Neurology, Mount Sinai School of Medicine, New York, New York.

Address correspondence and reprint requests to Dr. Kevin St. P. McNaught, Department of Neurology, Mount Sinai School of Medicine, Annenberg 14–73, One Gustave L. Levy Place, New York, NY 10029; e-mail: kevin.mcnaught{at}mssm.edu

The cause and mechanism of neuronal death in sporadic Parkinson's disease (PD) continue to elude investigators. Recently, alterations in proteasomal function have been detected in the brain of patients with the illness. The biochemical basis of the defect and its relevance to the disease process are now being studied. The available results suggest that proteasomal dysfunction could underlie protein accumulation, Lewy body formation, and neuron death in PD. The cause of proteasomal dysfunction is unknown at present, but this could relate to gene mutations, oxidative damage, ATP depletion, or the actions of environmental toxins. It remains to be established if proteasomal dysfunction plays a primary or a secondary role in the initiation or progression of the neurodegenerative process in PD.

This study was supported by grants from the Bachmann-Strauss Dystonia & Parkinson Foundation, Inc., the Bendheim Parkinson's Disease Center, the Morris and Alma Schapiro Fund, and the NIH/NINDS (1 RO1 NS045999–01).

Publication of this supplement was supported by an educational grant from Teva Neuroscience and Eisai, Inc.

Disclosure: The sponsor has provided KM with an honorarium for his participation in this project and personal honoraria during his professional career. The sponsor has provided CWO with personal honoraria (in excess of $10,000) during his professional career. TJ, RJ, and AK have not reported any conflicts of interest.

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