HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Data Supplement Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Castelo, J.M.B. Articles by Stern, C. E. Search for Related Content PubMed PubMed Citation Articles by Castelo, J.M.B. Articles by Stern, C. E.

Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding

From Cognitive Neuroimaging Laboratory (J.M.B., S.J.S., M.G.C., R.J.M., C.E.S.), Center for Memory and Brain, Boston University, MA; and Athinoula A. Martinos Center for Biomedical Imaging (C.E.S.), MGH/MIT/HMS, Charlestown, MA.

Address correspondence and reprint requests to J.M.B. Castelo, Center for Memory and Brain, 2 Cummington Street Rm. 105, Boston, MA 02215; e-mail: mboer{at}bu.edu

Objective: To investigate the integrity of hippocampal-prefrontal circuitry during episodic encoding in patients with HIV.

Methods: Functional MRI was used to observe changes in blood oxygenation level-dependent (BOLD) signal in 14 HIV-positive participants and 14 age- and education-matched control subjects while performing an episodic encoding task. Subjects also completed neuropsychological measures of attention and memory.

Results: Behavioral results revealed no significant differences in neuropsychological performance. The fMRI results revealed that while both groups recruited brain regions known to be important for successful encoding, including bilateral medial temporal lobes and inferior prefrontal gyri, the HIV group demonstrated significantly reduced signal intensity changes in the right posterior hippocampus, right inferior frontal gyrus, and left lingual gyrus. Additionally, the HIV group exhibited more activity within lateral frontal and posterior parietal regions.

Conclusions: This study demonstrates altered integrity of hippocampal-prefrontal regions during episodic encoding in HIV-positive patients. These results extend previous studies that have documented the effects of HIV on fronto-striatal circuits, and suggest the virus functionally impacts the hippocampal system as well.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 13 issue to find the title link for this article.

Supported by NIH grants RO1 NS40239 and F31 NS054570-01A1 and the NCRR RR14075.

Disclosure: The authors report no conflicts of interest.

Received July 28, 2005. Accepted in final form March 2, 2006.

This article has been cited by other articles:

				P. M. Maki, M. H. Cohen, K. Weber, D. M. Little, D. Fornelli, L. H. Rubin, P. Perschler, F. Gould, and E. Martin Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women: A preliminary study Neurology, May 12, 2009; 72(19): 1661 - 1668. [Abstract] [Full Text] [PDF]

				K. Schon, Y. T. Quiroz, M. E. Hasselmo, and C. E. Stern Greater Working Memory Load Results in Greater Medial Temporal Activity at Retrieval Cereb Cortex, February 18, 2009; (2009) bhp006v1. [Abstract] [Full Text] [PDF]