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NEUROLOGY 2006;66:1732-1735
© 2006 American Academy of Neurology
Brief Communications

Acute symptomatic seizures and hippocampus damage: DWI and MRS findings

Hemant Parmar, MD, Shih-Hui Lim, FRCP (Edin), Nigel C.K. Tan, MRCP and C. C. Tchoyoson Lim, FRCR

From the Departments of Neuroradiology (H.P., C.C.T.L.) and Neurology (S.-H.L., N.C.K.T.), National Neuroscience Institute, Singapore; and Division of Neuroradiology (H.P.), Department of Radiology, University of Michigan, Ann Arbor, MI; and Diagnostic Radiology (C.C.T.L.), National University of Singapore.

Address correspondence and reprint requests to Dr Tchoyoson Lim, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433; e-mail: tchoyoson_lim{at}nni.com.sg

The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with corresponding lactate detected on MRS in six patients and EEG seizure activity in nine patients. On follow-up, the atrophic hippocampus had an increased ADC in six patients. DWI and MRS may predict development of hippocampal sclerosis.

Supported by grant NHG-PTD/03004 from the Singapore Health Service.

Disclosure: The authors report no conflicts of interest.

This paper was presented at the 90th Radiologic Society of North America (RSNA) Scientific Assembly and Annual Meeting, Chicago, IL, December 2004.

Received December 23, 2005. Accepted in final form February 21, 2006.




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