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NEUROLOGY 2006;66:1739-1741
© 2006 American Academy of Neurology
Brief Communications

Rapid infusion of cold saline (4 °C) as adjunctive treatment of fever in patients with brain injury

Neeraj Badjatia, MD, Michael Bodock, PharmD, M. Guanci, CNRN and G. A. Rordorf, MD

From the Departments of Neurology (N.B., M.G., G.A.R.) and Pharmacy (M.B.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. Neeraj Badjatia, Division of Stroke and Critical Care, Columbia University College of Physicians and Surgeons, Neurological Institute, 710 West 168th Street, Box 29, New York NY 10032; e-mail: nbadjatia{at}neuro.columbia.edu

The use of rapid infusion of large-volume cold saline (CS) as an adjunctive therapy for treating refractory fever in nine patients is reported. A decline in temperature (39.2 ± 0.3 vs 37.1 ± 1.2 °C, p = 0.006) at 2 hours and fever burden (97.3 ± 343.8 vs 734.3 ± 422.3 °C*min, p = 0.02) at 12 hours was noted after CS bolus. Rapid infusion of large-volume CS may be used as an adjunct for inducing normothermia in refractory febrile patients.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 13 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received November 11, 2005. Accepted in final form February 22, 2006.




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