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Mortality of stroke patients treated with thrombolysis: Analysis of nationwide inpatient sample

From the University of Kansas Medical Center, Departments of Neurology (R.D.) and Preventive Medicine and Public Health (S.-M.L.), Kansas City, KS.

Address correspondence and reprint requests to Dr. Richard Dubinsky, Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd., Mail Stop 2012, Kansas City, KS 66160; e-mail: rdubinsky{at}safetyresearch.com or rdubinsk{at}kumc.edu

The authors performed a retrospective cohort comparison using the Nationwide Inpatient Sample for 1999 through 2002 of acute ischemic stroke admissions. Mortality was compared based on the use of thrombolysis. Hospital mortality was significantly greater for the thrombolysis cohort (10.1% vs 5.8%) as was the rate of secondary intracranial hemorrhage (4.2% vs 0.4%). US community experience in the use of thrombolysis has higher rates of complications and mortality than in controlled clinical trials.

Disclosure: The authors report no conflicts of interest.

Presented in part at the annual meeting of the American Academy of Neurology, April 2005.

Received November 11, 2005. Accepted in final form February 22, 2006.

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