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NEUROLOGY 2006;66:1747-1749
© 2006 American Academy of Neurology
Brief Communications

Cerebral perfusion changes during cataplexy in narcolepsy patients

Seung Bong Hong, MD, PhD, Woo Suk Tae, MS and Eun Yeon Joo, MD

From the Department of Neurology (W.S.T., S.B.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; and Department of Neurology (E.Y.J.), College of Medicine, Ewha Womans University, Seoul, Korea.

Address correspondence and reprint requests to Dr. Seung Bong Hong, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea; e-mail: sbhong{at}smc.samsung.co.kr

To localize cerebral perfusion differences during cataplexy, brain SPECT subtraction was performed between cataplexy and baseline awake period or REM sleep in patients with narcolepsy. During cataplexy, subtracted SPECT showed hyperperfusion in right amygdala, bilateral cingulate gyri, basal ganglia, thalami, premotor cortices, sensorimotor cortices, right insula, and brainstem, and hypoperfusion in prefrontal cortex and occipital lobe. This result suggests that cataplexy is produced by the activation of amygdalo-cortico-basal ganglia–brainstem circuit.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 13 issue to find the title link for this article.

Supported by grant A050462 from the Good Health R&D Project, Ministry of Health & Welfare, Republic of Korea.

Disclosure: The authors report no conflicts of interest.

Received December 1, 2005. Accepted in final form February 20, 2006.




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[Abstract] [Full Text] [PDF]


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