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Prospective prevalence of pathologic gambling and medication association in Parkinson disease

From the Human Motor Control Section (V.V.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; and Department of Psychiatry (V.V., M.Z., M.D.) and Division of Neurology (K.H., S.D.-C., S.F., A.E.L., J.M.), Toronto Western Hospital, Toronto, Canada.

Address correspondence and reprint requests to Dr. Valerie Voon, Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5S213, 10 Center Drive, Bethesda, MD 20892-1428; e-mail: voonv{at}ninds.nih.gov

The authors prospectively screened 297 patients with Parkinson disease (PD), who attended a tertiary clinic, using a modified South Oaks Gambling Scale. Lifetime prevalence of pathologic gambling (PG) was 3.4% and on any dopamine agonist was 7.2%. PG was associated with earlier PD onset and with dopamine agonists but not with agonist subtype or doses. We found no association with a potent D3 receptor agonist.

Disclosure: The authors report no conflicts of interest.

Received December 9, 2005. Accepted in final form February 17, 2006.

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