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From the GH Sergievsky Center (E.D.L., L.S.H.), Department of Neurology (E.D.L., L.S.H.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L., J.P.G.V., L.S.H.), and Department of Pathology (J.P.G.V.), College of Physicians and Surgeons, Columbia University, New York, NY; Veterans Affairs Pacific Islands Health Care System, Honolulu (G.W.R.); Departments of Medicine and Geriatrics (G.W.R.), University of Hawaii John A. Burns School of Medicine; Pacific Health Research Institute (G.W.R.), Kuakini Medical Center/Honolulu-Asia Aging Study (G.W.R.), Honolulu, HI; and Department of Neurology, University of Kansas Medical Center (K.E.L., R.P.), Kansas City, KS.
Address correspondence and reprint requests to Dr. Elan D. Louis, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY; e-mail: EDL2{at}columbia.edu
Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 13 issue to find the title link for this article.
Supported by R01 NS42859, AG08702, and AG07232 from the NIH, Bethesda, MD, and the International Essential Tremor Foundation, Lenexa, KS.
Disclosure: The authors report no conflicts of interest.
Received August 1, 2005. Accepted in final form February 21, 2006.
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