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NEUROLOGY 2006;66:1938-1940
© 2006 American Academy of Neurology
Brief Communications

Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy

L. E. Jeha, MD, I. M. Najm, MD, W. E. Bingaman, MD, F. Khandwala, MS, P. Widdess-Walsh, MD, H. H. Morris, MD, D. S. Dinner, MD, D. Nair, MD, N. Foldvary-Schaeffer, DO, R. A. Prayson, MD, Y. Comair, MD, FRCSC, R. O'Brien, PhD, J. Bulacio, MD, A. Gupta, MD and H. O. Lüders, MD, PhD

From the Departments of Neurology (L.E.J., I.M.N., P.W.-W., H.H.M., D.S.D., D.N., N.F.-S., H.O.L.), Neurosurgery (W.E.B.), Biostatistics (F.K., R.O.), and Pathology (R.A.P.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurosurgery, American University of Beirut, Lebanon (Y.C.); Department of Neurology, Hospital de Niños Santísima Trinidad, Córdoba, Argentina (J.B.); and Park Ridge Hospital (A.G.), Asheville, NC.

Address correspondence and reprint requests to Dr. Lara E. Jeha, Department of Neurology, S51, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: jehil{at}ccf.org

To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 to 14.1 years). Fifty-three percent of patients were seizure free at 10 years. The authors identified multiple predictors of recurrence. Results of EEG performed 6 months postoperatively correlated with occurrence and severity of seizure recurrence, in addition to breakthrough seizures with discontinuation of antiepileptic drugs.

Disclosure: The authors report no conflicts of interest.

Received May 19, 2005. Accepted in final form March 2, 2006.




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