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Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: A randomized controlled study

From the Department of Neurology (R.B.P., A.-L.L.), McGill University, Montreal General Hospital, Montreal, Quebec, Canada; Morton and Gloria Shulman Movement Disorders Center (A.J.E., C.Z., A.E.L.), Toronto Western Hospital, Toronto, Ontario, Canada; Department of Clinical Neurosciences (O.S., R.R.); and Movement Disorder Clinic (W.R.W.M., R.C.), University of Alberta, Edmonton, Alberta, Canada.

Address correspondence and reprint requests to Dr. Ronald B. Postuma, Department of Neurology, L7-305 Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4; e-mail: ron.postuma{at}muhc.mcgill.ca

Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B₁₂ 500 µg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 27 issue to find the title link for this article.

This study was supported by an unrestricted educational grant to AEL from Novartis, Canada. R.P. was supported by a fellowship from the Parkinson Society of Canada. A.E.L. holds a Center of Excellence award from the National Parkinson Foundation (Miami).

Disclosure: A.E.L. received honoraria from Novartis Canada for research not related to the current study during the course of this study.

Received September 19, 2005. Accepted in final form February 28, 2006.

This article has been cited by other articles:

				A. Di Rocco, P. Werner, R. B. Postuma, and A. E. Lang VITAMINS AND ENTACAPONE IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA: A RANDOMIZED CONTROLLED STUDY Neurology, April 24, 2007; 68(17): 1440 - 1441. [Full Text] [PDF]

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