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NEUROLOGY 2006;66:1946-1948
© 2006 American Academy of Neurology
Brief Communications

Anti-inflammatory cytokines in subclinical carotid atherosclerosis

Wojciech Ambrosius, MD, PhD, Radoslaw Kazmierski, MD, PhD, Slawomir Michalak, MD, PhD and Wojciech Kozubski, MD, PhD

From the Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

Address correspondence and reprint requests to Dr. Wojciech Ambrosius, Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland; e-mail: wambrosius{at}amp.edu.pl

Some studies have shown correlations between selected proinflammatory factors and carotid atherosclerosis. It has not been established whether anti-inflammatory cytokines are associated with carotid intima–media thickness (IMT), an ultrasound surrogate marker of atherosclerosis. Therefore, the authors studied the relationship between the carotid IMT and serum levels of interleukin (IL)-10 and transforming growth factor-ß1 in 76 subjects. They discovered that lower IL-10 levels were associated with increased mean IMT in common carotid arteries.

Disclosure: The authors report no conflicts of interest.

Presented in part at the 57th Annual Meeting of the American Academy of Neurology, April 9 through 16, 2005.

Received September 8, 2005. Accepted in final form March 10, 2006.






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