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NEUROLOGY 2006;66:1949-1950
© 2006 American Academy of Neurology
Brief Communications

Family history of dementia is a risk factor for Lewy body disease

B. K. Woodruff, MD, N. R. Graff-Radford, MD, T. J. Ferman, PhD, D. W. Dickson, MD, M. W. DeLucia, J. E. Crook, PhD, Z. Arvanitakis, MD, S. Brassler, C. Waters, W. Barker, MS and R. Duara, MD

From the Department of Neurology (Dr. Woodruff), Mayo Clinic Scottsdale, AZ; Departments of Neurology (N.R.G.-R.), Psychiatry and Psychology (T.J.F.), Pathology and Neuroscience (D.W.D., M.W.D.), and the Biostatistics Unit (J.E.C.), Mayo Clinic Jacksonville, FL; Department of Neurological Sciences (Z.A.), Rush University Medical Center, Chicago, IL; Orlando Regional Medical Center (S.B.), Orlando, FL; Holmes Regional Medical Center (C.W.), Melbourne, FL; and Mt. Sinai Medical Center and University of Miami School of Medicine (W.B., R.D.), Miami, FL.

Address correspondence and reprint requests to Dr. Bryan K. Woodruff, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, Arizona 85259; e-mail: woodruff.bryan{at}mayo.edu

Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD and AD compared with controls, suggesting that genetic factors are as important in LBD as they are in AD.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the June 27 issue to find the title link for this article.

This study was supported by grant P50-AG16574-01, the Florida AD Initiative, NIA R01-AG15866, the Mayo Foundation, and a grant by Clarice and Robert Smith.

Disclosure: The authors report no conflicts of interest.

Received February 4, 2005. Accepted in final form March 10, 2006.






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