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Brain volume loss in MCI predicts dementia

From the Department of Neurology (D.E-.L., D.H., M.M.M., J.Q., L.S., J.K.), Oregon Health and Science University, and Veteran's Affairs Medical Center (D.E.-L., J.Q., L.S., J.K.), Portland, OR.

Address correspondence and reprint requests to Dr. D. Erten-Lyons, Layton Aging and Alzheimer's Disease Center, 3181 SW Sam Jackson Park Rd., CR 131, Portland, OR 97239; e-mail: ertenlyo{at}ohsu.edu

Rates of temporal horn volume change were significantly greater in the subjects with mild cognitive impairment who were developing dementia vs those who remained stable.

Supported by the Merit Review Grant, Office of Research and Development, Department of Veterans Affairs, National Institute on Aging, NIH (AG08017, MO1 RR000334).

Disclosure: The authors report no conflicts of interest.

Received February 18, 2005. Accepted in final form October 4, 2005.

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