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NEUROLOGY 2006;66:247-249
© 2006 American Academy of Neurology
Brief Communications

Oligodendroglial tumor chemotherapy using "decreased-dose-intensity" PCV: A Singapore experience

A. U. Ty, MD, S. J. See, MD, J. P. Rao, MD, J.B.K. Khoo, MD, FRCR and M. C. Wong, FRCP

From the Department of Neurology (A.U.T., S.J.S., M.C.W.), National Neuroscience Institute (Singapore General Hospital campus); Department of Neurosurgery (J.P.R.), National Neuroscience Institute (Tan Tock Seng Hospital campus); and Division of Oncologic Imaging (J.B.K.K.) and Brain Tumor Research Laboratory, Division of Medical Sciences (M.C.W.), National Cancer Center, Singapore.

Address correspondence and reprint requests to Prof. Meng Cheong Wong, National Neuroscience Institute (Singapore General Hospital campus), Block 6, Level 8, Outram Road, Singapore 169608; e-mail: gnewmc{at}sgh.com.sg.

The authors propose "decreased-dose-intensity" PCV (procarbazine, lomustine [CCNU], and vincristine) chemotherapy for Asian patients with oligodendroglial tumors. In this study, all seven patients with oligodendroglioma (OD) and eight with anaplastic oligodendroglioma (AO) had objective responses or stable disease. Median progression-free survival was greater than 29 months (OD) and 36.5 months or greater (AO); 86% of patients with OD and 63% with AO remain progression-free. Twenty-four Common Toxicity Criteria Grade 3/4 adverse events were noted.

Disclosure: The authors report no conflicts of interest.

Received December 21, 2004. Accepted in final form October 10, 2005.






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