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NEUROLOGY 2006;66:259-261
© 2006 American Academy of Neurology
Brief Communications

Factors influencing nerve regeneration in a trial of timcodar dimesylate

M. Polydefkis, MD, M. Sirdofsky, MD, P. Hauer, BS, B. G. Petty, MD, B. Murinson, MD, PhD and J. C. McArthur, MBBS, MPH

From the Departments of Neurology (M.P., P.H., B.M., J.C.M.),Epidemiology (J.C.M.), Medicine and Clinical Pharmacology (B.G.P.), The Johns Hopkins University, Baltimore, MD; and Georgetown University Department of Neurology (M.S.), Washington, DC.

Address correspondence and reprint requests to Dr. Michael Polydefkis, The Johns Hopkins Hospital, 600 North Wolfe Street, Pathology 509, Baltimore, MD 21287; e-mail: mpolyde{at}jhmi.edu.

The authors assessed the ability of the neurophilin compound, timcodar dimesylate, to accelerate the return of epidermal nerve fiber density (ENFD) after a standardized nerve injury in a randomized double blind, placebo controlled trial. While there was no difference in the regeneration rate between the treatment and placebo arms, the baseline ENFD (p = 0.006), height (p = 0.02), and race (p = 0.03) were associated with the regeneration rate.

Supported by grants NS41374 (MP) and RR00522 (GCRC JHU) from the National Institutes of Health, the Juvenile Diabetes Research Foundation (MP), and Vertex Pharmaceuticals Inc.

Disclosure: The authors report no conflicts of interest.

Received December 8, 2005. Accepted in final form October 7, 2005.




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