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NEUROLOGY 2006;66:262-264
© 2006 American Academy of Neurology
Brief Communications

Seizures and their outcome in progressive multifocal leukoencephalopathy

Marco A. Lima, MD, Frank W. Drislane, MD and Igor J. Koralnik, MD

From the Department of Neurology (M.A.L., F.W.D., I.J.K.) and Division of Viral Pathogenesis (M.A.L., I.J.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and School of Medicine (M.A.L.), Federal University of Rio de Janeiro, Brazil.

Address correspondence and reprint requests to Dr Koralnik, Neurology Department, Beth Israel Deaconess Medical Center, Research East, Rm. 213C, 330 Brookline Ave., Boston, MA 02215; e-mail: ikoralni{at}bidmc.harvard.edu.

Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival. The presence of PML lesions immediately adjacent to the hemispheric cortex was the only risk factor associated with seizures in this population.

Supported in part by Public Health Service Grants R01 NS/AI 041198 and NS 047029 (I.J.K.) and by the Ellen R. Cavallo research fund. M.A.L. is the recipient of a Fellowship from the National Scientific and Technological Development Council, CNPq- Brazil.

Disclosure: The authors report no conflicts of interest.

Received June 28, 2005. Accepted in final form October 5, 2005.




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