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NEUROLOGY 2006;66:281-283
© 2006 American Academy of Neurology
Brief Communications

Detection of floccular hypometabolism in downbeat nystagmus by fMRI

R. Kalla, MD, A. Deutschlander, MD, K. Hufner, MD, T. Stephan, PhD, K. Jahn, MD, S. Glasauer, PhD, T. Brandt, MD, FRCP and M. Strupp, MD

From the Department of Neurology, University of Munich, Germany.

Address correspondence and reprint requests to Dr. Michael Strupp, Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: Michael.Strupp{at}med.uni-muenchen.de

The authors evaluated floccular activity with fMRI during the performance of vertical smooth pursuit eye movements in four patients with downbeat nystagmus (DBN) due to cerebellar degeneration and in 16 healthy controls. Region of interest analysis revealed a significantly diminished activation of both floccular lobes during downward but not upward pursuit in DBN. These imaging data support the view that a functional deficiency of the flocculi in downward pursuit causes DBN.

Supported by Deutsche Forschungsgemeinschaft (Gl 342/1-1), (BR 639/6-3).

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form October 10, 2005.




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