Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kalla, R.
Right arrow Articles by Strupp, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kalla, R.
Right arrow Articles by Strupp, M.
NEUROLOGY 2006;66:281-283
© 2006 American Academy of Neurology
Brief Communications

Detection of floccular hypometabolism in downbeat nystagmus by fMRI

R. Kalla, MD, A. Deutschlander, MD, K. Hufner, MD, T. Stephan, PhD, K. Jahn, MD, S. Glasauer, PhD, T. Brandt, MD, FRCP and M. Strupp, MD

From the Department of Neurology, University of Munich, Germany.

Address correspondence and reprint requests to Dr. Michael Strupp, Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: Michael.Strupp{at}med.uni-muenchen.de

The authors evaluated floccular activity with fMRI during the performance of vertical smooth pursuit eye movements in four patients with downbeat nystagmus (DBN) due to cerebellar degeneration and in 16 healthy controls. Region of interest analysis revealed a significantly diminished activation of both floccular lobes during downward but not upward pursuit in DBN. These imaging data support the view that a functional deficiency of the flocculi in downward pursuit causes DBN.

Supported by Deutsche Forschungsgemeinschaft (Gl 342/1-1), (BR 639/6-3).

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form October 10, 2005.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J N Wagner, M Glaser, T Brandt, and M Strupp
Downbeat nystagmus: aetiology and comorbidity in 117 patients
J. Neurol. Neurosurg. Psychiatry, June 1, 2008; 79(6): 672 - 677.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Dieterich and T. Brandt
Functional brain imaging of peripheral and central vestibular disorders
Brain, May 30, 2008; (2008) awn042v1.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Hufner, T. Stephan, R. Kalla, A. Deutschlander, J. Wagner, M. Holtmannspotter, G. Schulte-Altedorneburg, M. Strupp, T. Brandt, and S. Glasauer
Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmus
Neurology, September 11, 2007; 69(11): 1128 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Kalla, S. Glasauer, U. Buttner, T. Brandt, and M. Strupp
4-Aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus
Brain, September 1, 2007; 130(9): 2441 - 2451.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C. D. Cnyrim, N. Rettinger, U. Mansmann, T. Brandt, and M. Strupp
Central compensation of deviated subjective visual vertical in Wallenberg's syndrome
J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 527 - 528.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.