HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hadjivassiliou, M. Articles by Korponay-Szabó, I. R. Search for Related Content PubMed PubMed Citation Articles by Hadjivassiliou, M. Articles by Korponay-Szabó, I. R. Related Collections All Immunology Autoimmune diseases Gait disorders/ataxia

Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia

From the Departments of Neurology and Gastroenterology (M.H., R.A.G., D.S.S.), Royal Hallamshire Hospital, Sheffield; Biomedical Research Centre (C.A.W., N.M.W.), Sheffield Hallam University, Sheffield; and Coeliac Disease Study Group (M.M., I.R.K.-S.), Paediatric Research Centre, University of Tampere, Finland.

Address correspondence and reprint requests to Dr. M. Hadjivassiliou, Department of Clinical Neurology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; e-mail: m.hadjivassiliou{at}sheffield.ac.uk

Objective: To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker of the whole spectrum of gluten sensitivity) in the jejunal tissue and brain of patients with gluten ataxia and in control subjects.

Methods: The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ataxia for the presence of TG2-related immunoglobulin deposits using double-color immunofluorescence. Autopsy brain tissue from one patient with gluten ataxia and one neurologically intact brain were also studied.

Results: IgA deposition on jejunal TG2 was found in the jejunal tissue of all patients with gluten ataxia and in none of the controls. The intestinal IgA deposition pattern was similar to that seen in patients with overt and latent celiac disease and in those with dermatitis herpetiformis. Widespread IgA deposition around vessels was found in the brain of the patient with gluten ataxia but not the control brain. The deposition was most pronounced in the cerebellum, pons, and medulla.

Conclusions: Anti–tissue transglutaminase IgA antibodies are present in the gut and brain of patients with gluten ataxia with or without an enteropathy in a similar fashion to patients with celiac disease, latent celiac disease, and dermatitis herpetiformis but not in ataxia control subjects. This finding strengthens the contention that gluten ataxia is immune mediated and belongs to the same spectrum of gluten sensitivity as celiac disease and dermatitis herpetiformis.

Disclosure: The authors report no conflicts of interest.

Received June 7, 2005. Accepted in final form October 19, 2005.

This article has been cited by other articles:

				K. Kaukinen, P. Collin, and M. Maki Latent coeliac disease or coeliac disease beyond villous atrophy? Gut, October 1, 2007; 56(10): 1339 - 1340. [Full Text] [PDF]

				E. Harper, H. Moses, and A. Lagrange Occult celiac disease presenting as epilepsy and MRI changes that responded to gluten-free diet Neurology, February 13, 2007; 68(7): 533 - 534. [Full Text] [PDF]

				M Hadjivassiliou, R A Grunewald, R H Kandler, A K Chattopadhyay, J A Jarratt, D S Sanders, B Sharrack, S B Wharton, and G A B Davies-Jones Neuropathy associated with gluten sensitivity J. Neurol. Neurosurg. Psychiatry, November 1, 2006; 77(11): 1262 - 1266. [Abstract] [Full Text] [PDF]

				W. T. Hu, J. A. Murray, M. C. Greenaway, J. E. Parisi, and K. A. Josephs Cognitive impairment and celiac disease. Arch Neurol, October 1, 2006; 63(10): 1440 - 1446. [Abstract] [Full Text] [PDF]