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Oscillatory pallidal local field potential activity correlates with involuntary EMG in dystonia

From the Sobell Department of Motor Neuroscience and Movement Disorders (C.C.C., A.A.K., P.B.), Institute of Neurology, London, UK; Department of Neurology (C.C.C.), Chang Gung Memorial Hospital and University, Taipei, Taiwan; Departments of Neurology (A.A.K., A.K., T.T.), Radiology (K.-T.H.), and Neurosurgery (G.-H.S.), University Medicine Berlin, Charité Campus Virchow, Berlin, Germany; Departments of Neurosurgery (J.K.K.) and Neurology (J.C.W.), University Hospital, Klinikum Mannheim, Germany; CNRS UPR640 (E.B.) and INSERM U679 (J.Y.), Hôpital de la Salpêtrière, Paris, France.

Address correspondence and reprint requests to Dr. P. Brown, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WCIN 3BG, UK; e-mail: p.brown{at}ion.ac.uk

The pathophysiology of dystonia is unclear. The authors recorded local field potentials (LFPs) from deep brain stimulation electrodes implanted in the pallidum of 13 dystonic patients. LFP power correlated with the level of dystonic EMG in the sternocleidomastoid, with maximal positive correlations at the lower contacts of pallidal electrodes. The data suggest that the neuronal synchronization indexed by LFP oscillations in the globus pallidus may be mechanistically linked to dystonic EMG activity.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the February 14 issue to find the title link for this article.

C.C.C. is supported by a PhD studentship from Chang Gung Memorial Hospital, Taipei, Taiwan and a Graduate Open studentship from University College London; P.B. is supported by the Medical Research Council of Great Britain and A.K. is supported by a fellowship from the Charité, Berlin (Rahel Hirsch Habilitationsstipendium).

Disclosure: The authors report no conflicts of interest.

Received June 20, 2005. Accepted in final form October 24, 2005.

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