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Is protracted low-dose temozolomide feasible in glioma patients?

From the Departments of Medical Oncology (A.T., L.P., V.B., A.A.B.), Neurological Sciences (E.M.), and Pathology (M.G.), University Hospital of Padova; Department of Medical Oncology (G.C., L.S., E.F.), Bellaria Hospital, Bologna; and Department of Pathology (C.G.), Verona Hospital, Italy.

Address correspondence and reprint requests to Dr. Alba A. Brandes, Department of Medical Oncology, Azienda Ospedale-Università, Ospedale Busonera, Via Gattamelata 64, 35100 Padova, Italy; e-mail: aabrandes{at}unipd.it

The authors investigated the safety of 75 mg/m² temozolomide for 21 days every 28 days in glioma patients. This schedule could lead to DNA repair enzyme O⁶-alkylguanine-DNA alkyltransferase depletion, contributing to overcoming drug resistance. Although Phase III studies are forthcoming, no data are available on the long-term toxicity of temozolomide, which, in this series, incurred prolonged, cumulative lymphopenia, which leads to a high incidence of infections.

Disclosure: Dr. Brandes has had an advisory role with Schering-Plough. The remaining authors report no conflicts of interest.

Presented in part at the Poster Session of the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, May 13 through 17, 2005.

Received July 14, 2005. Accepted in final form October 25, 2005.

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