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NEUROLOGY 2006;66:442-443
© 2006 American Academy of Neurology
Brief Communications

Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy

M. Linnebank, MD, S. Kemp, PhD, R.J.A. Wanders, PhD, W. J. Kleijer, PhD, M. L.T. van der Sterre, J. Gärtner, MD, K. Fliessbach, MD, A. Semmler, MD, P. Sokolowski, MD, W. Köhler, MD, U. Schlegel, MD, S. Schmidt, MD, T. Klockgether, MD and U. Wüllner, MD, PhD

From the Department of Neurology (M.L., A.S., U.S., S.S., T.K., U.W.), University Hospital Bonn, Bonn, Germany; Department of Pediatrics and Clinical Chemistry (S.K., R.J.A.W.), University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; Department of Clinical Genetics (W.J.K., M.L.T.V.), Erasmus Medical Center, Rotterdam, The Netherlands; Department Pediatrics (J.G.), University Hospital Göttingen, Göttingen, Germany; Department of Epileptology (K.F.), University Hospital Bonn, Bonn, Germany; Department of Neurology (P.S., W.K.), Sächsisches Krankenhaus Hubertusburg, Wermsdorf, Germany; Department of Neurology (U.S.), University Hospital Bochum, Knappschaftskrankenhaus, Bochum, Germany.

Address correspondence and reprint requests to Dr. Michael Linnebank, University Hospital Bonn, D-53105 Bonn, Germany; e-mail: michael.linnebank{at}ukb.uni-bonn.de

A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("pure" AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy.

Disclosure: The authors report no conflicts of interest.

Received August 22, 2005. Accepted in final form October 20, 2005.




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[Abstract] [Full Text] [PDF]


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