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Outcome and effect of pregnancy in myotonic dystrophy type 2

From the Institute for Human Genetics (S.R-S., U.R., K.Z.), RWTH Aachen University, Aachen, Germany; Department of Neurology (C.S.-G.), University of Göttingen, Göttingen, Germany; the Institute for Human Genetics (W.K.), University of Würzburg, Würzburg, Germany; and the Friedrich Baur Institute (B.G.H.S.), Department of Neurology, Ludwig-Maximilians University Munich, Munich, Germany.

Address correspondence and reprint requests to Dr. Sabine Rudnik-Schöneborn, Institut für Humangenetik, RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany; e-mail: srudnik-schoeneborn{at}ukaachen.de

The authors reviewed the obstetric histories of 42 women of 37 families with myotonic dystrophy type 2 (DM2). Nine women (21%) had the first symptoms during pregnancy and worsening in subsequent pregnancies. Of 96 pregnancies, 13% ended as early and 4% as late miscarriages. Preterm labor occurred in 50% of pregnancies resulting in 27% preterm deliveries in women with overt DM2 in pregnancy. There was no evidence of a congenital DM2.

Disclosure: The authors report no conflicts of interest.

Received June 28, 2005. Accepted in final form October 27, 2005.

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