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Published online before print January 25, 2006, doi:10.1212/01.wnl.0000200777.96896.3d)
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NEUROLOGY 2006;66:727-729
© 2006 American Academy of Neurology
Brief Communications

Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage: A pilot study

J. A. Frontera, MD, T. Rundek, MD, J. M. Schmidt, PhD, J. Claassen, MD, A. Parra, MD, K. E. Wartenberg, MD, R. E. Temes, MD, S. A. Mayer, MD, J. P. Mohr, MD and R. S. Marshall, MD

From the Department of Neurology, Division of Stroke and Neurocritical Care, Columbia University College of Physicians and Surgeons, New York, NY.

Address correspondence and reprint requests to Randolph Marshall, MD, Neurological Institute, 710 W. 168th Street, 6th Floor, New York, NY 10032; e-mail: rsm2{at}columbia.edu

The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2R and in none of 6 patients with preserved reactivity (p = 0.011). Abnormal CO2R preceded the onset of vasospasm in 7 of 9 patients. Abnormal standard TCD testing was not associated with vasospasm.

Editorial, see page 622

See also page 634

This article was previously published in electronic format as an Expedited E-Pub on January 25, 2006, at www.neurology.org.

Supported by a Seed Grant from the American Medical Association, the Charles and Jean Brunie Fund, and a Grant-in-Aid from the American Heart Association to Dr. Mayer (#9750432N).

Disclosure: The authors report no conflicts of interest.

Received June 8, 2005. Accepted in final form December 7, 2005.




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Correspondence:

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Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage
George KC Wong, et al.
Neurology Online, 8 Mar 2006 [Full text]
Reply from the authors
Jennifer A. Frontera, et al.
Neurology Online, 8 Mar 2006 [Full text]