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Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage: A pilot study

From the Department of Neurology, Division of Stroke and Neurocritical Care, Columbia University College of Physicians and Surgeons, New York, NY.

Address correspondence and reprint requests to Randolph Marshall, MD, Neurological Institute, 710 W. 168th Street, 6th Floor, New York, NY 10032; e-mail: rsm2{at}columbia.edu

The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO₂R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO₂R and in none of 6 patients with preserved reactivity (p = 0.011). Abnormal CO₂R preceded the onset of vasospasm in 7 of 9 patients. Abnormal standard TCD testing was not associated with vasospasm.

Editorial, see page 622

See also page 634

This article was previously published in electronic format as an Expedited E-Pub on January 25, 2006, at www.neurology.org.

Supported by a Seed Grant from the American Medical Association, the Charles and Jean Brunie Fund, and a Grant-in-Aid from the American Heart Association to Dr. Mayer (#9750432N).

Disclosure: The authors report no conflicts of interest.

Received June 8, 2005. Accepted in final form December 7, 2005.

This article has been cited by other articles:

				J. A. Frontera, A. Fernandez, J. M. Schmidt, J. Claassen, K. E. Wartenberg, N. Badjatia, E. S. Connolly, and S. A. Mayer Defining Vasospasm After Subarachnoid Hemorrhage: What Is the Most Clinically Relevant Definition? Stroke, June 1, 2009; 40(6): 1963 - 1968. [Abstract] [Full Text] [PDF]

				G. K.C. Wong, S. C.P. Ng, W. W.S. Poon, J. A. Frontera, and R. S. Marshall Cerebrovascular reactivity and vasospasm after subarachnoid hemorrhage: A pilot study Neurology, June 13, 2006; 66(11): 1787 - 1787. [Full Text] [PDF]

				A. A. Rabinstein The blood and the vessel: Prediction of cerebral vasospasm after subarachnoid hemorrhage Neurology, March 14, 2006; 66(5): 622 - 623. [Full Text] [PDF]

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