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NEUROLOGY 2006;66:733-736
© 2006 American Academy of Neurology
Brief Communications

Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers

J. Li, MD, Z. Zhuang, MD, PhD*, H. Okamoto, MD, A. O. Vortmeyer, MD, D. M. Park, MD, M. Furuta, MD, Y. S. Lee, MD, E. H. Oldfield, MD, W. Zeng, MD, PhD and R. J. Weil, MD*

From Surgical Neurology Branch (J.L., Z.Z., H.O., A.O.V., D.M.P., M.F. Y.-S.L., E.H.O., W.Z., R.J.W.), National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Brain Tumor Institute (W.Z., R.J.W.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurosurgery (M.F.), Saga Medical School, Saga, Japan; Department of Pathology (Y.-S.L.), Catholic University, Seoul, Korea; Department of Pathology (W.Z.), Zhongshan Medical College of Sun-Yat Sen University, Guangzhou, China.

Address correspondence and reprint requests to Dr. Robert J. Weil, Brain Tumor Institute, Cleveland Clinic Foundation, ND4-40 Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: weilr{at}ccf.org

Methods to permit more precise delineation of astrocytomas of different grades may have therapeutic utility. The authors selectively microdissected pure populations of cells from normal brain and astrocytomas. They performed two-dimensional protein gel electrophoresis (2DGE) followed by protein sequencing. Differential expression was confirmed immunohistochemically. 2DGE identified proteomic patterns and proteins that differentiated normal brain from tumor and distinguished astrocytomas of increasing grade.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 14 issue to find the title link for this article.

*These authors contributed equally.

Supported in part by the NIH, National Center for Research Resources, by the General Clinical Research Center Grant M01 RR-018390 to the Cleveland Clinic Foundation, and by the Melvin Burkhardt Chair in neuro-oncology research.

Disclosure: The authors report no conflicts of interest.

Received June 24, 2005. Accepted in final form November 22, 2005.






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