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Somatosensory cortical atrophy after spinal cord injury: A voxel-based morphometry study

From the Department of Physiology (M.T.J., M.C.V.), University of Toronto, Toronto; Department of Medical Imaging (M.T.J., A.P.C., D.J.M.), Toronto Western Hospital of the University Health Network, Toronto; Departments of Physical Therapy and Rehabilitation Science (M.C.V.), University of Toronto, Toronto; Toronto Rehabilitation Institute (M.C.V.), Toronto; Department of Surgery (M.G.F.), Toronto Western Hospital of the University Health Network, Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. David J. Mikulis, Department of Medical Imaging, Toronto Western Hospital, McLaughlin 3MC-431, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8; e-mail: mikulis{at}uhnres.utoronto.ca

The authors used voxel-based morphometry to compare sensorimotor cortical gray and white matter volume on structural MR images of a group of 17 individuals with cervical spinal cord injury (SCI) and a group of 17 healthy subjects. SCI subjects had reduced gray matter volume bilaterally in primary somatosensory cortex (p < 0.001). These findings suggest that the somatosensory cortex of the human brain atrophies after SCI.

Supported by the Ontario Neurotrauma Foundation and the Natural Sciences and Engineering Research Council of Canada.

Disclosure: The authors report no conflicts of interest.

Received May 3, 2005. Accepted in final form November 22, 2005.

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