Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murugappan, A.
Right arrow Articles by Levine, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murugappan, A.
Right arrow Articles by Levine, S. R.
Related Collections
Right arrow All Clinical trials
Right arrow All Cerebrovascular disease/Stroke
Right arrow Clinical trials Observational study (Cohort, Case control)
Right arrow Infarction
Right arrowRelated Article
NEUROLOGY 2006;66:768-770
© 2006 American Academy of Neurology
Brief Communications

Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan, MD, W. M. Coplin, MD, A. N. Al-Sadat, MD, K. J. McAllen, PharmD, L. H. Schwamm, MD, L. R. Wechsler, MD, C. S. Kidwell, MD, J. L. Saver, MD, S. Starkman, MD, Y. P. Gobin, MD, G. Duckwiler, MD, M. Krueger, MD, G. Rordorf, MD, J. P. Broderick, MD, G. E. Tietjen, MD and S. R. Levine, MD

From the Stroke and Neurosciences Critical Care Programs, Departments of Neurology (A.M., W.M.C., A.N.A.-S.), Neurological Surgery (W.M.C.), and Pharmacy Administration (K.J.M.), Wayne State University, School of Medicine, Detroit, MI; the Departments of Neurology: Massachusetts General Hospital (L.H.S., G.R.), Boston, MA; University of Pittsburgh (L.R.W.), Pittsburgh, PA; University of Cincinnati (J.P.B.), Cincinnati, OH; Medical University of Ohio at Toledo (G.E.T.), Toledo, OH; The Mount Sinai School of Medicine and Stroke Center (S.R.L.), New York, NY; and the Departments of Neurology (C.S.K., J.L.S., S.S., G.D.), Emergency Medicine (S.S., M.K.), and Radiology (Y.P.G.), University of California, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Steven R. Levine, Stroke Center, Box 1137, Department of Neurology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574; e-mail: steven.levine{at}mssm.edu

The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 14 issue to find the title link for this article.

Supported in part by NIH grants NS 38905 (W.M.C.) and 43992 (S.R.L.).

Disclosure: The authors report no conflicts of interest.

Received June 30, 2005. Accepted in final form November 28, 2005.


Related Article

March 14 Highlights
Neurology 2006 66: 620-621. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
A. Roth and U. Elkayam
Acute myocardial infarction associated with pregnancy.
J. Am. Coll. Cardiol., July 15, 2008; 52(3): 171 - 180.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
S D Treadwell, B Thanvi, and T G Robinson
Stroke in pregnancy and the puerperium
Postgrad. Med. J., May 1, 2008; 84(991): 238 - 245.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C A Davie and P O'Brien
Stroke and pregnancy
J. Neurol. Neurosurg. Psychiatry, March 1, 2008; 79(3): 240 - 245.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. De Keyser, Z. Gdovinova, M. Uyttenboogaart, P. C. Vroomen, and G. J. Luijckx
Intravenous Alteplase for Stroke: Beyond the Guidelines and in Particular Clinical Situations
Stroke, September 1, 2007; 38(9): 2612 - 2618.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. Aleu, P. Mellado, C. Lichy, M. Kohrmann, and P. D. Schellinger
Hemorrhagic Complications After Off-Label Thrombolysis for Ischemic Stroke
Stroke, February 1, 2007; 38(2): 417 - 422.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. D. Bushnell, P. Hurn, C. Colton, V. M. Miller, G. del Zoppo, M. S.V. Elkind, B. Stern, D. Herrington, G. Ford-Lynch, P. Gorelick, et al.
Advancing the Study of Stroke in Women: Summary and Recommendations for Future Research From an NINDS-Sponsored Multidisciplinary Working Group
Stroke, September 1, 2006; 37(9): 2387 - 2399.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.