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NEUROLOGY 2006;66:768-770
© 2006 American Academy of Neurology
Brief Communications

Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan, MD, W. M. Coplin, MD, A. N. Al-Sadat, MD, K. J. McAllen, PharmD, L. H. Schwamm, MD, L. R. Wechsler, MD, C. S. Kidwell, MD, J. L. Saver, MD, S. Starkman, MD, Y. P. Gobin, MD, G. Duckwiler, MD, M. Krueger, MD, G. Rordorf, MD, J. P. Broderick, MD, G. E. Tietjen, MD and S. R. Levine, MD

From the Stroke and Neurosciences Critical Care Programs, Departments of Neurology (A.M., W.M.C., A.N.A.-S.), Neurological Surgery (W.M.C.), and Pharmacy Administration (K.J.M.), Wayne State University, School of Medicine, Detroit, MI; the Departments of Neurology: Massachusetts General Hospital (L.H.S., G.R.), Boston, MA; University of Pittsburgh (L.R.W.), Pittsburgh, PA; University of Cincinnati (J.P.B.), Cincinnati, OH; Medical University of Ohio at Toledo (G.E.T.), Toledo, OH; The Mount Sinai School of Medicine and Stroke Center (S.R.L.), New York, NY; and the Departments of Neurology (C.S.K., J.L.S., S.S., G.D.), Emergency Medicine (S.S., M.K.), and Radiology (Y.P.G.), University of California, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Steven R. Levine, Stroke Center, Box 1137, Department of Neurology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574; e-mail: steven.levine{at}mssm.edu

The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the March 14 issue to find the title link for this article.

Supported in part by NIH grants NS 38905 (W.M.C.) and 43992 (S.R.L.).

Disclosure: The authors report no conflicts of interest.

Received June 30, 2005. Accepted in final form November 28, 2005.


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Neurology 2006 66: 620-621. [Full Text]  



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