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From the Department of Neurology (J.V., C.D., G.K., M.K., C.H., H.B., R.B.L.) and Department of Epidemiology and Population Health (A.L., C.D., C.H., R.B.L.), Albert Einstein College of Medicine, Bronx, NY.
Address correspondence and reprint requests to Dr. Verghese, Einstein Aging Study, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Room 338, Bronx, New York 10461; e-mail: jverghes{at}aecom.yu.edu
Objective: To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI).
Methods: The authors examined the relationship between baseline level of participation in leisure activities and risk of aMCI in a prospective cohort of 437 community-residing subjects older than 75 years, initially free of dementia or aMCI, using Cox analysis adjusted for age, sex, education, and chronic illnesses. The authors derived Cognitive and Physical Activity Scales based on frequency of participation in individual activities.
Results: Over a median follow-up of 5.6 years, 58 subjects had development of aMCI. A one-point increase on the Cognitive (hazard ratio [HR] 0.95, 95% CI 0.91 to 0.99) but not Physical Activities Scale (HR 0.97, 95% CI 0.93 to 1.01) was associated with lower risk of aMCI. Subjects with Cognitive Activity scores in the highest (HR 0.46, 95% CI 0.24 to 0.91) and middle thirds (HR 0.52, 95% CI 0.29 to 0.96) had a lower risk of aMCI compared with subjects in the lowest third. The association persisted even after excluding subjects who converted to dementia within 2 years of meeting criteria for aMCI.
Conclusions: Cognitive activity participation is associated with lower risk of development of amnestic mild cognitive impairment, even after excluding individuals at early stages of dementia.
Editorial, see page 794
See also page 911
This article was previously published in electronic format as an Expedited E-Pub on February 8, 2006, at www.neurology.org.
The Einstein Aging Study is supported by National Institutes on Aging program project grant (AGO3949). Dr. Verghese is supported by a Paul B Beeson Career Development Award (NIA-K23 AG024848) and RO1 AGO25119.
Disclosure: The authors report no conflicts of interest.
This article was orally presented in part at the Third Annual Mild Cognitive Impairment symposium, Mt. Sinai Medical Center, Miami, Florida, in March 2005 and at the Annual Meeting of the American Geriatrics Society at Orlando, Florida, in May 2005.
Received August 30, 2005. Accepted in final form November 8, 2005.
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