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This Article Figures Only Full Text Full Text (PDF) CME: Take the course for this article: Volume 66, Number 6, March 28, 2006 Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moroni, I. Articles by Pareyson, D. Search for Related Content PubMed PubMed Citation Articles by Moroni, I. Articles by Pareyson, D. Related Collections Peripheral neuropathy All Pediatric

Childhood-onset multifocal motor neuropathy with conduction blocks

From the Departments of Child Neurology (I.M., M.B.), Developmental Neurology (R.B.), Clinical Neurophysiology (C.C.), and Biochemistry and Genetics (D.P.), National Neurological Institute "C. Besta," Milano, Italy.

Address correspondence and reprint requests to Dr. I. Moroni, Department of Child Neurology, National Neurological Institute "C. Besta," via Celoria 11, 20133 Milano, Italy; e-mail: imoroni{at}istituto-besta.it

Multifocal motor neuropathy (MMN) is an acquired disorder with onset in adulthood. The authors describe a patient with a slowly progressing distal upper limb motor neuropathy since age 6 years, in whom definite conduction blocks in upper limbs, outside common entrapment sites, and no sensory involvement were consistent with MMN. IV immunoglobulin treatment produced marked muscle strength improvement and conduction block disappearance. MMN diagnosis should also be considered in childhood.

Disclosure: The authors report no conflicts of interest.

Received August 10, 2005. Accepted in final form December 5, 2005.