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NEUROLOGY 2006;66:935-937
© 2006 American Academy of Neurology
Brief Communications

Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB

T. Mori, MD, M. Ikeda, MD, PhD, R. Fukuhara, MD, PhD, P. J. Nestor, PhD, FRACP and H. Tanabe, MD, PhD

From the Department of Neuropsychiatry (T.M., M.I., R.F., H.T.), Ehime University School of Medicine, Ehime, Japan; and University of Cambridge, Neurology Unit, Addenbrooke’s Hospital (P.J.N.), Cambridge, United Kingdom.

Address correspondence and reprint requests to Dr. Manabu Ikeda, Department of Neuropsychiatry, Ehime University School of Medicine, Toon city, Ehime 791-0295, Japan; e-mail: mikeda{at}m.ehime-u.ac.jp

The authors explored the neural substrate of visual hallucinations in dementia with Lewy bodies (DLB) by investigating changes in regional cerebral blood flow (rCBF) and psychiatric symptoms, before and after cholinesterase inhibitor treatment. Twenty subjects with DLB were treated with donepezil for a 12-week period. Hallucinations attenuated while receiving therapy, whereas occipital rCBF focally increased, suggesting that functional visual association cortex deficits may cause visual hallucinations in patients with DLB.

Supported by the Higher Brain Function Groups of the Department of Neuropsychiatry, Ehime University School of Medicine.

Disclosure: The authors report no conflicts of interest.

Received May 16, 2005. Accepted in final form December 8, 2005.




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