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NEUROLOGY 2006;66:938-940
© 2006 American Academy of Neurology
Brief Communications

Relationship between Helicobacter pylori infection and Alzheimer disease

J. Kountouras, MD, PhD, M. Tsolaki, MD, PhD, E. Gavalas, MD, M. Boziki, MD, C. Zavos, MD, P. Karatzoglou, MD, D. Chatzopoulos, MD and I. Venizelos, MD, PhD

From the Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital (J.K., E.G., C.Z., P.K., D.C., I.V.); and Third Neurological Clinic, Aristotle University of Thessaloniki, Papanikolaou Hospital (M.T., M.B.), Thessaloniki, Greece.

Address correspondence and reprint requests to Dr. Jannis Kountouras, 8 Fanariou St., Byzantio 551 33, Thessaloniki, Macedonia, Greece; e-mail: jannis{at}med.auth.gr

The authors investigated the association between Helicobacter pylori infection (Hp-I) and Alzheimer disease (AD) by using histology for diagnosis of Hp-I. Fifty patients with AD and 30 iron deficiency anemic control participants without AD were included. The histologic prevalence of Hp-I was 88% in patients with AD and 46.7% in controls (p < 0.001).

Disclosure: The authors report no conflicts of interest.

Received August 11, 2005. Accepted in final form December 6, 2005.




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