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NEUROLOGY 2006;66:1088-1090
© 2006 American Academy of Neurology
Brief Communications

Motor system inhibition in dopa-responsive dystonia and its modulation by treatment

Y. -Z. Huang, PhD, I. Trender-Gerhard, MD, M. J. Edwards, MBBS, P. Mir, MD, J. C. Rothwell, PhD and K. P. Bhatia, MD

From the Department of Neurology (Y.-Z.H.), Chang Gung Memorial Hospital, Taipei, Taiwan; Sobell Department of Motor Neuroscience and Movement Disorders (Y.-Z.H., I.T.-G., M.J.E., P.M., J.C.R., K.P.B.), Institute of Neurology, University College London, UK; and Servicio de Neurología (P.M.), Hospital Universitario Virgen del Rocío, Seville, Spain.

Address correspondence and reprint requests to Dr Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, WC1N 3BG, UK; e-mail: k.bhatia{at}ion.ucl.ac.uk

Dopa-responsive dystonia (DRD) causes dystonia–parkinsonism, which is abolished by levodopa. The authors assessed short intracortical inhibition and facilitation, silent period, blink reflex recovery cycle, and reciprocal inhibition in seven patients with DRD on and off treatment. Short intracortical inhibition and blink reflex recovery cycle were reduced, but increased with treatment. Silent period was normal on and off treatment. Third phase of reciprocal inhibition was reduced on and off treatment. A discrete pattern of motor inhibitory dysfunction occurs in DRD.

Commentary, see page 959

See also page 1091

Funded by the Medical Research Council (MRC UK).

Disclosure: The authors report no conflicts of interest.

Received April 18, 2005. Accepted in final form February 8, 2006.


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April 11 Highlights and Commentary: Abnormal circuit function in dystonia
Neurology 2006 66: 959. [Full Text] [PDF]



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