|
© 2006 American Academy of Neurology Brief Communications Motor system inhibition in dopa-responsive dystonia and its modulation by treatmentFrom the Department of Neurology (Y.-Z.H.), Chang Gung Memorial Hospital, Taipei, Taiwan; Sobell Department of Motor Neuroscience and Movement Disorders (Y.-Z.H., I.T.-G., M.J.E., P.M., J.C.R., K.P.B.), Institute of Neurology, University College London, UK; and Servicio de Neurología (P.M.), Hospital Universitario Virgen del Rocío, Seville, Spain. Address correspondence and reprint requests to Dr Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, WC1N 3BG, UK; e-mail: k.bhatia{at}ion.ucl.ac.uk Dopa-responsive dystonia (DRD) causes dystonia–parkinsonism, which is abolished by levodopa. The authors assessed short intracortical inhibition and facilitation, silent period, blink reflex recovery cycle, and reciprocal inhibition in seven patients with DRD on and off treatment. Short intracortical inhibition and blink reflex recovery cycle were reduced, but increased with treatment. Silent period was normal on and off treatment. Third phase of reciprocal inhibition was reduced on and off treatment. A discrete pattern of motor inhibitory dysfunction occurs in DRD.
Commentary, see page 959 See also page 1091 Funded by the Medical Research Council (MRC UK). Disclosure: The authors report no conflicts of interest. Received April 18, 2005. Accepted in final form February 8, 2006.
Related Articles
This article has been cited by other articles:
|
||||||||||||||||||||||||
