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NEUROLOGY 2006;66:1091-1093
© 2006 American Academy of Neurology
Brief Communications

Changes in forearm reciprocal inhibition following pallidal stimulation for dystonia

S. Tisch, MBBS, P. Limousin, MD, PhD, J. C. Rothwell, PhD, P. Asselman, L. Zrinzo, MD, M. Jahanshahi, PhD, K. P. Bhatia, MD and M. I. Hariz, MD, PhD

From the Unit of Functional Neurosurgery (S.T., P.L., L.Z., M.J., M.I.H.), Sobell Department Motor Neuroscience and Movement Disorders (S.T., P.L., J.C.R., P.A., L.Z., M.J., K.P.B., M.I.H.), Institute of Neurology, Queen Square London, United Kingdom.

Address correspondence and reprint requests to Dr. Patricia Limousin, Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom; e-mail: p.limousin{at}ion.ucl.ac.uk

The authors recorded forearm H reflex reciprocal inhibition and clinical outcome in eight patients with primary torsion dystonia before and 1, 3, and 6 months after pallidal deep brain stimulation (DBS). There was progressive increase in reciprocal inhibition after surgery, which correlated with clinical improvement. The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition.

Commentary, see page 959

See also page 1088

Dr. Stephen Tisch is supported by the Brain Research Trust UK, Dr. Limousin and Prof. Hariz are supported by the Parkinson's Appeal UK, Prof. Rothwell and Mr. Asselman are supported by the MRC UK, and Prof. Jahanshahi is supported by the National Institute of Neurological Disorders and Stroke, NIH.

Disclosure: The authors report no conflicts of interest.

Received August 24, 2005. Accepted in final form January 10, 2006.


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