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NEUROLOGY 2006;66:1100-1102
© 2006 American Academy of Neurology
Brief Communications

{alpha}-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

K. J. Klos, MD, J. E. Ahlskog, MD, PhD, K. A. Josephs, MD, MST, H. Apaydin, MD, J. E. Parisi, MD, B. F. Boeve, MD, M. W. DeLucia, BS and D. W. Dickson, MD

From the Departments of Neurology (K.J.K., J.E.A., K.A.J., B.F.B.) and Laboratory Medicine and Pathology (J.E.P.), Mayo Clinic, Rochester, MN; Department of Neurology (H.A.), Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey; Department of Neuroscience and Neuropathology (M.W.D., D.W.D.), Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Dr. Dennis W. Dickson, Departments of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: dickson.dennis{at}mayo.edu

The authors assessed the frequency of spinal cord {alpha}-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age (N = 106). Using {alpha}-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some {alpha}-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse {alpha}-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.

Supported by the Morris K. Udall PD Research Center of Excellence (P50 NS40256), Mayo AD Research Center (P50 AG16754), and Mayo AD Patient Registry (U01 AG06786).

Disclosure: The authors report no conflicts of interest.

Received May 23, 2005. Accepted in final form December 19, 2005.




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